11/11/2014 AT 11:45 PM EST
"Howard!" It was one word but it conveyed so much when Carol Ann Susi yelled it.
The actress, who played Mrs. Wolowitz on the hit CBS sitcom The Big Bang Theory , died on Tuesday after a brief battle with an aggressive cancer. She was 62.
While viewers never saw her face on the show, Susi was nevertheless a strong presence, giving a loud voice to Howard's (Simon Helberg) larger-than-life, domineering mother.
"The Big Bang Theory family has lost a beloved member today with the passing of Carol Ann Susi," Warner Bros. and the show's producers, Chuck Lorre, Steve Molaro and Bill Prady, said in a statement. "Unseen by viewers, the Mrs. Wolowitz character became a bit of a mystert throughout the show's eight season. What was not a mystery, however, was Carol Ann's immense talent and comedic timing, which were on display during each unforgettable appearance."
"In addition to her talent, Carol Ann was a constant source of joy and kindness to all," the statement continued. "Our thoughts and deepest condolences are with her family during this time, and we will miss her greatly."
Seinfeld fans will remember New York-born Susi as the daughter of an unemployment officer who went out on a horrible date with George (Jason Alexander). She also guest-stared in Cheers, Doogie Howser, M.D., Grey's Anatomy, Married … with Children and That '70s Show.
Susi is survived by her brother, Michael Susi, and his wife, Connie.
"My heart is broken," her Big Bang Theory costar Kunal Nayyar Tweeted on Tuesday night. "I will miss your smile. Your spirit is forever with us."
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